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mirtazapine  (Bio-Techne corporation)


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    Bio-Techne corporation mirtazapine
    Mirtazapine, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 91/100, based on 523 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mirtazapine/Mirtazapine/custom%402018%4042504881
    Average 91 stars, based on 523 article reviews
    mirtazapine - by Bioz Stars, 2026-10
    91/100 stars

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    Related Articles

    Lysis:

    Article Title: CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes
    Article Snippet: PrePrint: 3mg/kg, diluted in vehicle (5% EtOH, 5%DMSO), at SE+3h, +1D, +2D, +3D, +4D, +7D, +10D, +14D. Eight rats from group 3 were treated i.p. according to the same schedule with another CB2 agonist, JWH-133 (Tocris) at a dose of 1.5 mg/kg diluted in the same vehicle. The doses of GP1a and JWH-133 were chosen according to the literature ( Braun et al., 2018 ; Li et al., 2018 ; Tang et al., 2016 ; Zarruk et

    Sonication:

    Article Title: CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes
    Article Snippet: PrePrint: 3mg/kg, diluted in vehicle (5% EtOH, 5%DMSO), at SE+3h, +1D, +2D, +3D, +4D, +7D, +10D, +14D. Eight rats from group 3 were treated i.p. according to the same schedule with another CB2 agonist, JWH-133 (Tocris) at a dose of 1.5 mg/kg diluted in the same vehicle. The doses of GP1a and JWH-133 were chosen according to the literature ( Braun et al., 2018 ; Li et al., 2018 ; Tang et al., 2016 ; Zarruk et

    Incubation:

    Article Title: CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes
    Article Snippet: PrePrint: 3mg/kg, diluted in vehicle (5% EtOH, 5%DMSO), at SE+3h, +1D, +2D, +3D, +4D, +7D, +10D, +14D. Eight rats from group 3 were treated i.p. according to the same schedule with another CB2 agonist, JWH-133 (Tocris) at a dose of 1.5 mg/kg diluted in the same vehicle. The doses of GP1a and JWH-133 were chosen according to the literature ( Braun et al., 2018 ; Li et al., 2018 ; Tang et al., 2016 ; Zarruk et

    Staining:

    Article Title: CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes
    Article Snippet: PrePrint: 3mg/kg, diluted in vehicle (5% EtOH, 5%DMSO), at SE+3h, +1D, +2D, +3D, +4D, +7D, +10D, +14D. Eight rats from group 3 were treated i.p. according to the same schedule with another CB2 agonist, JWH-133 (Tocris) at a dose of 1.5 mg/kg diluted in the same vehicle. The doses of GP1a and JWH-133 were chosen according to the literature ( Braun et al., 2018 ; Li et al., 2018 ; Tang et al., 2016 ; Zarruk et

    Enzyme-linked Immunosorbent Assay:

    Article Title: CB2 activation during epileptogenesis recruits immunomodulatory monocytes and mitigates cognitive, affective and seizure outcomes
    Article Snippet: PrePrint: 3mg/kg, diluted in vehicle (5% EtOH, 5%DMSO), at SE+3h, +1D, +2D, +3D, +4D, +7D, +10D, +14D. Eight rats from group 3 were treated i.p. according to the same schedule with another CB2 agonist, JWH-133 (Tocris) at a dose of 1.5 mg/kg diluted in the same vehicle. The doses of GP1a and JWH-133 were chosen according to the literature ( Braun et al., 2018 ; Li et al., 2018 ; Tang et al., 2016 ; Zarruk et



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    a Chemical structure of <t>MRT-31619,</t> OUN20985 (CRBN homo-PROTAC) and Lenalidomide. b , c Global quantitative proteomics in Jurkat cells. Volcano plots <t>show</t> <t>compound/DMSO</t> protein abundance upon treatment with 1 μM of MRT-31619 or CRBN homo-PROTAC for 1 h, 3 h and 24 h, and with 10 μM of MRT-31619 or CRBN homo-PROTAC for 24 h. d HEK293T_HiBiT-CRBN cells were treated with MRT-31619 for 1 h. Bortezomib at 2 μM, MLN4924 at 2 μM, and lenalidomide at 20 μM were added 1 h prior to MRT-31619 treatment. Values were normalized to DMSO treatment. Four biological replicates were plotted as mean ± Standard Deviation (SD). e HEK293T_HiBiT-CRBN cells were treated with CRBN homo-PROTAC for 1 h. Bortezomib at 2 μM, MLN4924 at 2 μM, and lenalidomide at 20 μM were added 1 h prior to CRBN homo-PROTAC treatment. Values were normalized to DMSO treatment. Four biological replicates were plotted as mean ± SD. f NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc constructs upon MRT-31619 or lenalidomide treatment. In the double treatment condition, lenalidomide was added at 20 μM, 1 h prior to MRT-31619 treatment. Values were normalized to DMSO treatment. Three biological replicates were plotted as mean ± Standard Error of Measurement (SEM). g NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc (CRBN-Nluc) wild-type (WT) and W386A constructs upon MRT-31619 treatment. Values were normalized to DMSO treatment. Three biological replicates were plotted as mean ± SEM. Source data are provided as a Source Data file.
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    a Chemical structure of MRT-31619, OUN20985 (CRBN homo-PROTAC) and Lenalidomide. b , c Global quantitative proteomics in Jurkat cells. Volcano plots show compound/DMSO protein abundance upon treatment with 1 μM of MRT-31619 or CRBN homo-PROTAC for 1 h, 3 h and 24 h, and with 10 μM of MRT-31619 or CRBN homo-PROTAC for 24 h. d HEK293T_HiBiT-CRBN cells were treated with MRT-31619 for 1 h. Bortezomib at 2 μM, MLN4924 at 2 μM, and lenalidomide at 20 μM were added 1 h prior to MRT-31619 treatment. Values were normalized to DMSO treatment. Four biological replicates were plotted as mean ± Standard Deviation (SD). e HEK293T_HiBiT-CRBN cells were treated with CRBN homo-PROTAC for 1 h. Bortezomib at 2 μM, MLN4924 at 2 μM, and lenalidomide at 20 μM were added 1 h prior to CRBN homo-PROTAC treatment. Values were normalized to DMSO treatment. Four biological replicates were plotted as mean ± SD. f NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc constructs upon MRT-31619 or lenalidomide treatment. In the double treatment condition, lenalidomide was added at 20 μM, 1 h prior to MRT-31619 treatment. Values were normalized to DMSO treatment. Three biological replicates were plotted as mean ± Standard Error of Measurement (SEM). g NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc (CRBN-Nluc) wild-type (WT) and W386A constructs upon MRT-31619 treatment. Values were normalized to DMSO treatment. Three biological replicates were plotted as mean ± SEM. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

    doi: 10.1038/s41467-025-65094-3

    Figure Lengend Snippet: a Chemical structure of MRT-31619, OUN20985 (CRBN homo-PROTAC) and Lenalidomide. b , c Global quantitative proteomics in Jurkat cells. Volcano plots show compound/DMSO protein abundance upon treatment with 1 μM of MRT-31619 or CRBN homo-PROTAC for 1 h, 3 h and 24 h, and with 10 μM of MRT-31619 or CRBN homo-PROTAC for 24 h. d HEK293T_HiBiT-CRBN cells were treated with MRT-31619 for 1 h. Bortezomib at 2 μM, MLN4924 at 2 μM, and lenalidomide at 20 μM were added 1 h prior to MRT-31619 treatment. Values were normalized to DMSO treatment. Four biological replicates were plotted as mean ± Standard Deviation (SD). e HEK293T_HiBiT-CRBN cells were treated with CRBN homo-PROTAC for 1 h. Bortezomib at 2 μM, MLN4924 at 2 μM, and lenalidomide at 20 μM were added 1 h prior to CRBN homo-PROTAC treatment. Values were normalized to DMSO treatment. Four biological replicates were plotted as mean ± SD. f NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc constructs upon MRT-31619 or lenalidomide treatment. In the double treatment condition, lenalidomide was added at 20 μM, 1 h prior to MRT-31619 treatment. Values were normalized to DMSO treatment. Three biological replicates were plotted as mean ± Standard Error of Measurement (SEM). g NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc (CRBN-Nluc) wild-type (WT) and W386A constructs upon MRT-31619 treatment. Values were normalized to DMSO treatment. Three biological replicates were plotted as mean ± SEM. Source data are provided as a Source Data file.

    Article Snippet: Cells were treated for 3 h with DMSO (Sigma Cat#41639) at 0.1% final concentration, MRT compounds or lenalidomide (Selleckchem Cat#S1029) at serial dilution using a Tecan D300e Digital Dispenser.

    Techniques: Quantitative Proteomics, Standard Deviation, Construct

    a The cis CRBN (CRBN 1 ) binds one MRT-31619 molecule (MGD 1 ) at the tri-tryptophan pocket and interacts with the trans MRT-31619 molecule (MGD 2 ) via a hydrogen bond to W400. b CRBN W400 interacts with the CK1α G-loop via a hydrogen bond in the presence of lenalidomide. c Superposition of panels a and b indicates that MGD 2 is a structural mimic of the CK1α G-loop and employs the same hydrogen bond. d – f Chemical structures of MRT-31619, MRT-31015, or MRT-30568 and their corresponding global quantitative proteomics data in Jurkat cells. Volcano plots show compound/DMSO protein abundance upon treatment with 10 μM of MRT-31619, MRT-31015, or MRT-30568 for 24 h. g HEK293T_HiBiT-CRBN degradation upon MRT-31619, MRT-31015, or MRT-30568 treatment for 1 h. Four biological replicates were plotted as mean ± SD. h NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc constructs upon MRT-31619, MRT-31015, or MRT-30568 treatment. Three biological replicates were plotted as mean ± SEM. i Flow-induced dispersion analysis (FIDA) for MRT-31619, MRT-31015, or MRT-30568 and the corresponding EC 50 and Max R h values. The predicted value of R h calculated from the cryo-EM structure of the ternary complex is 7.47 nm. Three biological replicates were plotted as mean ± SD. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

    doi: 10.1038/s41467-025-65094-3

    Figure Lengend Snippet: a The cis CRBN (CRBN 1 ) binds one MRT-31619 molecule (MGD 1 ) at the tri-tryptophan pocket and interacts with the trans MRT-31619 molecule (MGD 2 ) via a hydrogen bond to W400. b CRBN W400 interacts with the CK1α G-loop via a hydrogen bond in the presence of lenalidomide. c Superposition of panels a and b indicates that MGD 2 is a structural mimic of the CK1α G-loop and employs the same hydrogen bond. d – f Chemical structures of MRT-31619, MRT-31015, or MRT-30568 and their corresponding global quantitative proteomics data in Jurkat cells. Volcano plots show compound/DMSO protein abundance upon treatment with 10 μM of MRT-31619, MRT-31015, or MRT-30568 for 24 h. g HEK293T_HiBiT-CRBN degradation upon MRT-31619, MRT-31015, or MRT-30568 treatment for 1 h. Four biological replicates were plotted as mean ± SD. h NanoBRET assay for HaloTag-CRBN and CRBN-NanoLuc constructs upon MRT-31619, MRT-31015, or MRT-30568 treatment. Three biological replicates were plotted as mean ± SEM. i Flow-induced dispersion analysis (FIDA) for MRT-31619, MRT-31015, or MRT-30568 and the corresponding EC 50 and Max R h values. The predicted value of R h calculated from the cryo-EM structure of the ternary complex is 7.47 nm. Three biological replicates were plotted as mean ± SD. Source data are provided as a Source Data file.

    Article Snippet: Cells were treated for 3 h with DMSO (Sigma Cat#41639) at 0.1% final concentration, MRT compounds or lenalidomide (Selleckchem Cat#S1029) at serial dilution using a Tecan D300e Digital Dispenser.

    Techniques: Quantitative Proteomics, Construct, Dispersion, Cryo-EM Sample Prep